Fangchinoline
Fangchinoline CAS 436-77-1 Molecular Weight：608.74 Formula：C37H40N2O6
Purity: HPLC98%
Appearance： Off-white powder
Test Method： HPLC; Mass;NMR
Usage: For laboratory research use only,not for human or diganostic use。
Package 20mg~1g per bottle。
Storage： Store in a well closed container, protected from air and light.
Prepare and use solutions at the time of testing. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
Plant Origin
Stephania tetrandra S.Moore
Description
Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549.
References
[1]. Fangchinoline as a kinase inhibitor targets FAK and suppresses FAK-mediated signaling pathway in A549. PUMID/DOI：25539072
J Drug Target. 2015 Apr;23(3):266-74.
Fangchinoline effectively suppressed proliferation and invasion of A549 cell line but not NCI-H292, NCI-H446, and NCI-H460 cell lines by inhibiting the phosphorylation of FAK (Tyr397) and its downstream pathways, due to the significant differences of Fak expression between A549 and the other three cell lines. And all FAK-paxillin/MMP2/MMP9 pathway, FAK-Akt pathway, and FAK-MEK-ERK1/2 pathway could be inhibited by Fangchinoline.
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