Arenobufagin
Arenobufagin CAS 464-74-4 Molecular Weight：416.514 Formula：C24H32O6
Purity: HPLC98%
Appearance： White powder
Test Method： HPLC; Mass;NMR
Usage: For laboratory research use only,not for human or diganostic use。
Package 20mg~1g per bottle。
Storage： Store in a well closed container, protected from air and light.
Prepare and use solutions at the time of testing. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
Plant Origin
Venenum Bufonis．
Description
1.Arenobufagin intercalates with DNA leading to G2 cell cycle arrest via ATM/ATR pathway.Arenobufagin blocked the transition from G2 to M phase of cell cycle through inhibiting the activation of CDK1-Cyclin B1 complex.
2.Inhibition of phosphatidylinositol 3-kinase (PI3K)/Akt/mammalian target of rapamycin (mTOR) pathway by arenobufagin. Inhibition of mTOR by rapamycin or siRNA duplexes augmented arenobufagin-induced apoptosis and autophagy.
3.Arenobufagin might directly bind
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