Cucurbitacin B

Cucurbitacin B
Cucurbitacin B          CAS   6199-67-3         Molecular Weight：558.712  Formula：C32H46O8 

Purity:                 HPLC98%
Appearance：    White powder
Test Method：    HPLC; Mass;NMR
Usage:                 For laboratory research use only,not for human or diganostic use。
Package              20mg~1g per bottle。
Storage：           Store in a well closed container, protected from air and light.
Prepare and use solutions at the time of testing. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.

Plant Origin
The Dry pedicle and stalk of CucumismeloL．

Description
1.cucurbitacin B protects against cardiac hypertrophy through increasing the autophagy level in cardiomyocytes, which is associated with the inhibition of Akt/mTOR/FoxO3a signal axis
  2. Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells.

References

[1]. Xiao Y,etal. Cucurbitacin B Protects Against Pressure Overload Induced Cardiac Hypertrophy. J Cell Biochem. 2017 Nov;118(11):3899-3910.

[2]Jing Liang,etal.Cucurbitacin B inhibits the migration and invasion of breast cancer cells by altering the biomechanical properties of cells.Phytother Res. 2018 Dec 12.

Hongying Zhang

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