Bakuchiol
Bakuchiol CAS 10309-37-2 Molecular Weight：256.389 Formula：C18H24O
Purity: HPLC98%
Appearance： Light yellow oily liquid
Test Method： HPLC; Mass;NMR
Usage: For laboratory research use only,not for human or diganostic use。
Package 20mg~1g per bottle。
Storage： Store in a well closed container, protected from air and light.
Prepare and use solutions at the time of testing. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20℃. Generally, these will be useable for up to two weeks.
Plant Origin
Psoralea corylifolia L. Fruit drupaceous Psoralea p. rupacea Bunge
Description
[1]Among the tested UGT2B isoforms, UGT2B7 was inhibited by the strongest intensity. The noncompetitive inhibition was demonstrated by the results obtained from Dixon plot and Lineweaver-Burk plot. The Ki value was calculated to be 10.7 µM. In combination with the reported concentration after an intravenous administration of bakuchiol (15 mg/kg) in rats, the high risk of in vivo inhibition of bakuchiol towards UGT2B7-catalyzed metabolism of drugs was indicated
[2]Bakuchiol was an active antifungal compound isolated from Psoraleae Fructus by means of bioassay-guided fractionation in our previous study. The present work aimed to investigate the underlying mechanisms and the therapeutic effect of bakuchiol in Trichophyton mentagrophytes-induced tinea pedis
References
[1]. Xu Y, et al. In vitro evidence for bakuchiol's influence towards drug metabolism through inhibition of UDP-glucuronosyltransferase (UGT) 2B7. Afr Health Sci. 2014 Sep;14(3):564-9.
[2]. Lau KM, et al. Anti-dermatophytic activity of bakuchiol: in vitro mechanistic studies and in vivo tinea pedis-inhibiting activity in a guinea pig model. Phytomedicine. 2014 Jun 15;21(7):942-5.
Baoji Herbest Bio-Tech Co.,Ltd
Tel:0086-917-8883868
Fax: 0086-917-2769633
QQ： 1697104023
Email: info@herbest.cn
Web: http:www.herbest.cn
